Bone Sarcoma

Overview

The most frequent primary pediatric bone cancer is osteosarcoma, which arises from primitive bone-forming (osteoid generating) mesenchymal cells. It can be classified as primary (no underlying bone pathology) or secondary (underlying pathology that has undergone malignant degeneration/conversion), accounting for around 20% of all primary bone tumors.

Osteosarcoma manifests itself in a highly heterogeneous manner, allowing it to be subdivided into various subgroups based on the degree of differentiation, location within the bone, and histological variance. The imaging appearance, demographics, and biological activity of these sarcomas are widely variable when compared to other bone tumors.

Treatment choices and survivorship have dramatically improved in recent years thanks to the relentless efforts of several medical, surgical, and scientific specialists.