Carcinomatosis

Overview

Carcinomatosis is defined as a situation in which many carcinomas form at the same time, generally as a result of secondary spread from a primary source. It denotes more than just illness spread to regional nodes, and even more than simply metastatic disease. The word is commonly understood to signify that there are several secondary schools in various locations.

Several gastrointestinal and gynecological cancers have the ability to spread and develop in the peritoneal cavity. Peritoneal carcinomatosis (PC) has been proven to significantly reduce overall survival in patients with gastrointestinal cancer liver and/or extraperitoneal metastases.

Understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread, as well as the protective function of the peritoneal barrier against tumoral seeding, over the last three decades, has prompted the concept that PC is a loco-regional disease: in the absence of other systemic metastases, multimodal approaches combining aggressive cytoreductive surgery, intraperitoneal hyperthermic chemotherapy, and systemic chemotherapy