Multiple Malformation Syndrome

Three to five percent of live-born newborns have significant congenital abnormalities, while a further three percent have mild abnormalities. The central nervous system and the heart are often involved in 15-20% of the major congenital anomalies in liveborn infants.

The proportion of clinical issues attributable to congenital malformations has increased with the advancement of antenatal, intrapartum, postnatal, and infant care, and about 20% of pediatric admissions are brought on by genetic disorders, including single gene disorders, chromosomal abnormalities, exposures to teratogens, and multifactorial genetic disorders.

Congenital defects now account for almost as many deaths in the US as premature birth does. Congenital abnormalities will soon overtake other causes of neonatal death as a result of the ongoing advancements in perinatal care.

Multiple congenital abnormalities (MCAs) in a newborn pose challenging diagnostic and therapeutic challenges. The seemingly limitless lists of illnesses with perplexing eponyms and complex jumbles of traits may be overwhelming, not to mention a lack of experience with syndromes. This is made worse by the intensely emotional context in which decisions must be made.