Systemic Lupus Erythematosus (SLE)

Overview

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, resulting in extensive inflammation and tissue destruction in the organs involved. It has the potential to harm the joints, skin, brain, lungs, kidneys, and blood vessels. There is no cure for lupus, but medical treatments and lifestyle adjustments can help keep it under control.

The loss of immunological tolerance against self-antigens is influenced by genetic, immunological, endocrine, and environmental variables, resulting in the development of pathogenic autoantibodies that induce tissue damage via numerous pathways.

SLE diagnosis can be difficult, and while numerous categorization criteria have been proposed, their value in the clinical situation is still debatable. SLE management is controlled by organ system involvement, and despite various medicines that have been demonstrated to be effective in the treatment of SLE, the illness still poses a high morbidity and mortality risk in patients.